血脑屏障与免疫炎症反应

被引：10

作者：

王世召

张立民

张云鹤

付爱军

机构：

[1] 华北理工大学附属医院神经外科

来源：

中国临床神经外科杂志 | 2015年 / 20卷 / 07期

关键词：

血脑屏障; 炎症反应; 关系;

D O I：

10.13798/j.issn.1009-153X.2015.07.021

中图分类号：

R741 [神经病学];

学科分类号：

100204 [神经病学];

摘要：

<正>血脑屏障(blood brain barrier,BBB)严格调节血管与脑组织之间的离子、蛋白分子以及细胞的转运,是维持中枢神经系统内环境稳定的结构基础[1]。功能正常的BBB可以阻止进入体内的毒素、药物以及自身免疫系统对神经组织的损伤。在很多神经系统疾病(脑卒中、颅脑损伤、多发性硬化等)中,BBB损伤是多种继发性病理生理变化的基础,又是一系列因素损害的结果,还是引发脑水肿、颅内压增高和内

引用

页码：439 / 442

页数：4

共 8 条

[1]

Abnormal blood–brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI.[J].S.P. Cramer;H. Simonsen;J.L. Frederiksen;E. Rostrup;H.B.W. Larsson.NeuroImage: Clinical.2014,

[2]

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease.[J].Michelle A Erickson;William A Banks.Journal of Cerebral Blood Flow & Metabolism.2013, 10

[3]

Early inhibition of MMP activity in ischemic rat brain promotes expression of tight junction proteins and angiogenesis during recovery [J].

Yang, Yi ;

Thompson, Jeffrey F. ;

Taheri, Saeid ;

Salayandia, Victor M. ;

McAvoy, Thera A. ;

Hill, Jeff W. ;

Yang, Yirong ;

Estrada, Eduardo Y. ;

Rosenberg, Gary A. .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2013, 33 (07) :1104-1114

[4]

Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking.[J]..Journal of Autoimmunity.2010, 2

[5]

Role of Interleukin-1β in Early Brain Injury After Subarachnoid Hemorrhage in Mice [J].

Sozen, Takumi ;

Tsuchiyama, Reiko ;

Hasegawa, Yu ;

Suzuki, Hidenori ;

Jadhav, Vikram ;

Nishizawa, Shigeru ;

Zhang, John H. .

STROKE, 2009, 40 (07) :2519-2525

[6]

Upregulation of vascular growth factors in multiple sclerosis: Correlation with MRI findings.[J].Jen Jen Su;Manabu Osoegawa;Takeshi Matsuoka;Motozumi Minohara;Masahito Tanaka;Takaaki Ishizu;Futoshi Mihara;Takayuki Taniwaki;Jun-ichi Kira.Journal of the Neurological Sciences.2005, 1

[7]

Hydrogen peroxide-induced alterations of tight junction proteins in bovine brain microvascular endothelial cells [J].

Lee, HS ;

Namkoong, K ;

Kim, DH ;

Kim, KJ ;

Cheong, YH ;

Kim, SS ;

Lee, WB ;

Kim, KY .

MICROVASCULAR RESEARCH, 2004, 68 (03) :231-238

[8]

Simultaneous activation of several second messengers in hypoxia‐induced hyperpermeability of brain derived endothelial cells.[J].SilviaFischer;MarionWiesnet;Hugo H.Marti;DieterRenz;WolfgangSchaper.J. Cell. Physiol..2003, 3

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