大鼠脑缺血再灌流时检测血中脑细胞胞浆酶的意义

被引:5
作者
张洪
童萼塘
梅元武
孙圣刚
机构
[1] 同济医科大学附属协和医院神经内科
关键词
大鼠; 脑缺血; 再灌流; 胞浆酶;
D O I
暂无
中图分类号
R741.02 [神经病理学、病因学];
学科分类号
0710 ; 071006 ;
摘要
目的 :研究大鼠脑缺血灌流时脑细胞胞浆酶含量的变化及其临床意义。方法 :采用全自动生化分析仪检测血清肌酸激酶 ( CK)、肌酸激酶脑型同工酶 ( CK-BB)、乳酸脱氢酶 ( LDH)以及天门冬氨酸氨基转换酶 ( AST)的含量。结果 :脑缺血 2 0 min,血中 CK、CK-BB和 LDH的含量明显高于假手术组 ( P<0 .0 5或 P<0 .0 1 )。脑缺血再灌流后血中 CK、CK-BB、LDH和 AST的含量明显高于假手术组和脑缺血组 ( P<0 .0 1 )。结论 :脑缺血再灌流时血中胞浆酶的活性增加 ,检测血中胞浆酶含量可反映脑缺血组再灌流时细胞膜的损害程度。
引用
收藏
页码:17 / 18
页数:2
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