白塞病的免疫遗传学研究进展

被引:5
作者
李超然
郑文洁
机构
[1] 中国医学科学院北京协和医学院北京协和医院风湿免疫科
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R597.9 [];
学科分类号
摘要
<正>白塞病(Behcet's disease)是一种以血管炎为病理基础的慢性、复发性、多系统受累的全身性疾病。白塞病的病因及发病机制尚不明确,目前认为是遗传、感染、免疫和环境等多种因素共同作用的结果。在病毒、细菌感染等触发因素作用下,其微生物代谢产物(如热休克蛋白)被Toll样受体(TLR)等模式识别受体识别,启动天然免疫,继而激活获得性免疫,导致T细胞稳态破坏,产生辅助性T细胞(T helper cell,Th) 1和Th17为主的免疫反应,导致机体的炎症和损伤。白塞病的地域和种族差异以及家族聚集倾向提示遗传因
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