固体脂质体纳米粒制备方法的研究进展

被引：20

作者：

冯炜玮

陈志伟

机构：

[1] 山东理工大学生命科学学院

来源：

中国医药生物技术 | 2011年 / 6卷 / 03期

关键词：

D O I：

暂无

中图分类号：

R943 [制剂学];

学科分类号：

100702 [药剂学];

摘要：

<正>固体脂质纳米粒(solid lipid nanoparticles,SLN)又称固体脂质体,是一种室温下为固态的天然或合成的脂质体或类脂纳米粒子。SLN的研究始于20世纪90年代,是一种以硬脂酸、卵磷脂、三酰甘油等脂类原料为基质,将药物包裹于类脂核中制成50～1000nm粒径的固体脂质粒子给药体系[1-2]。SLN常温下为固态,具有以下四方面特点:①良好的生物兼容性;②能有效地控制药物释放,并可有效避免药物的降解和泄漏;③适合于多种给药途径;④稳定性好,能提

引用

页码：218 / 221

页数：4

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