共轭亚油酸诱导人胃腺癌细胞(SGC-7901)凋亡的作用

被引：11

作者：

刘家仁

陈炳卿

邓皓

韩晓辉

刘瑞海

机构：

[1] 哈尔滨医科大学公共卫生学院!黑龙江哈尔滨

[2] 哈尔滨医科大学第二临床医学院ICU!黑龙江哈尔滨

[3] 美国康奈尔大学食品科学系!Ithaca

[4] NY

[5] -

来源：

工业卫生与职业病 | 2001年 / 03期

关键词：

共轭亚油酸(c9,t11-CLA); 胃腺癌细胞(SGC-7901); 细胞凋亡;

D O I：

10.13692/j.cnki.gywsyzyb.2001.03.001

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

摘要：

目的　研究共轭亚油酸单体 (c9,t11-CLA)诱导人体胃腺癌细胞 (SGC - 790 1)凋亡作用。方法　采用细胞生长曲线 ,凋亡细胞的荧光显微镜、电镜观察 ,流式细胞光度术的检测以及P5 3蛋白表达方法。结果　显示出c9,t11-CLA对SGC - 790 1细胞有明显的抑制作用 ,并可诱导SGC - 790 1细胞产生凋亡 ,并随着c9,t11-CLA浓度的增加 ,细胞凋亡率逐渐增加 ;而P5 3蛋白表达则随着c9,t11-CLA浓度的增加呈逐渐降低的趋势。结论　这可能是c9,t11-CLA抑制肿瘤细胞机制之一。

引用

页码：129 / 133

页数：5

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