封闭负压引流联合生物敷料对糖尿病足溃疡创面植皮后血管新生、炎症反应的影响

被引：34

作者：

卫东

杜丽萍

张家建

机构：

[1] 四川省人民医院四川省医学科学院电子科技大学附属医院整形美容科

来源：

海南医学院学报 | 2017年 / 23卷 / 15期

关键词：

糖尿病足; 封闭负压引流; 生物敷料; 血管新生; 炎症反应;

D O I：

10.13210/j.cnki.jhmu.20170810.018

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症];

学科分类号：

100201 [内科学];

摘要：

目的:研究封闭负压引流联合生物敷料对糖尿病足溃疡创面植皮后血管新生、炎症反应的影响。方法:选择2014年5月2017年2月在四川省人民医院就诊的糖尿病足患者,随机分为负压引流组和常规对照组,分别使用封闭负压引流联合生物敷料以及常规清创换药来处理创面。治疗前及治疗后1、3、5d时,采集创面组织并检测血管新生分子、血管新生通路信号分子、炎症反应分子的表达量。结果:治疗后1、3、5d时,负压吸引组创面组织中血管内皮生长因子（VEGF）、VEGFR、CD105、基质金属蛋白酶（MMP）9、PI3K、AKT、cyclinD1、p38MAPK、NF-κB的蛋白表达量均显著高于常规对照组（P<0.05）,COX-2、iNOS、肿瘤坏死因子（TNF）-α、白介素（IL）-6的mRNA表达量均显著低于常规对照组（P<0.05）。结论:封闭负压引流联合生物敷料对糖尿病足溃疡创面植皮后的血管新生具有促进作用,炎症反应具有抑制作用。

引用

页码：2071 / 2074

页数：4

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