雌激素受体α及β亚型与绝经后骨质疏松的关系

被引：12

作者：

商敏

机构：

[1] 北京友谊医院妇产科

来源：

中国骨质疏松杂志 | 2010年 / 16卷 / 04期

关键词：

绝经后骨质疏松; 雌激素受体;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

绝经后雌激素水平下降是绝经后骨质疏松症发病的主要原因,随着年龄增长和绝经后体内雌激素水平降低,骨细胞上的ER的数量和功能均降低,可以部分解释绝经后妇女骨质疏松症发生率骤升的现象,骨细胞上的ER与绝经后骨质疏松症发生有重要的关系。ERα和ERβ在不同部位的骨骼及不同的骨细胞中分布有所差异,二者在骨代谢中可能行使着不同的功能,本文就此进行了详细的综述。

引用

页码：295 / 299

页数：5

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