成骨细胞Toll样受体4信号通路研究进展

被引：19

作者：

廖萌

严孙杰

机构：

[1] 福建医科大学第一附属医院内分泌科

来源：

中华骨质疏松和骨矿盐疾病杂志 | 2013年 / 6卷 / 03期

关键词：

Toll样受体4; 成骨细胞; 信号通路; 骨质疏松;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

Toll样受体4(TLR4)为天然免疫的关键模式识别受体,在骨丢失发病机制中发挥重要作用。TLR4通路与影响成骨细胞的其他通路如Wnt/β-catenin、TGF-β/BMP、Notch通路间存在密切联系。TLR4通路通过抑制NF-κB配体受体活化剂(RANKL)、骨保护素(OPG)、碱性磷酸酶(ALP)等成骨相关标志物表达抑制成骨细胞的分化、增殖、矿化等。TLR4通路还能促进成骨细胞凋亡、降低骨密度。本文就TLR4结构、功能及其对成骨细胞的作用进行综述。

引用

页码：260 / 265

页数：6

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