急性ST段抬高性心肌梗死急诊PCI冠脉无复流患者红细胞渗透脆性变化及意义

被引：4

作者：

叶明

聂绍平

机构：

[1] 首都医科大学附属北京安贞医院急诊危重症中心

来源：

河北医药 | 2014年 / 36卷 / 15期

关键词：

急性ST段抬高性心肌梗死; 急诊PCI; 冠脉无复流; 红细胞渗透脆性;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

1002 ; 100201 ;

摘要：

目的观察急性ST段抬高性心肌梗死急诊PCI无复流患者红细胞渗透脆性的变化,并探讨可能的机制和临床意义。方法选取急性ST段抬高性心肌梗死行急诊PCI患者120例,其中60例急诊PCI过程中出现冠脉无复流现象,为无复流组;其余60例未出现无复流现象者为对照组。取入院即刻2组外周静脉血5 ml,检测红细胞渗透脆性、红细胞膜Na+-K+-ATP酶活性、血浆脂质过氧化产物MDA及过氧化物歧化酶SOD的变化,并分析导致红细胞渗透脆性变化的原因及其临床意义。结果与对照组比较,无复流组患者红细胞渗透脆性明显降低(P<0.01),红细胞膜Na+-K+-ATP酶活性降低(P<0.05),血浆MDA水平升高(P<0.01),SOD含量减低(P<0.01)。结论急性ST段抬高性心肌梗死急诊PCI冠脉无复流患者红细胞渗透脆性降低会造成红细胞变形性下降,心肌微血管灌注不足,可能是造成预后不良的因素之一。造成无复流组患者红细胞渗透脆性降低的原因可能与红细胞膜Na+-K+-ATP酶活性降低、血浆脂质过氧化增强有关。

引用

页码：2250 / 2252

页数：3

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