肿瘤血管生成抑制剂CA-4的合成

被引:5
作者
杨兆琪
邱国福
粱淑彩
胡先明
机构
[1] 武汉大学药学院
[2] 武汉大学药学院 武汉
[3] 武汉
关键词
抗肿瘤; 合成;
D O I
10.13748/j.cnki.issn1007-7693.2005.03.012
中图分类号
TQ463 [有机化合物药物的生产];
学科分类号
1007 ;
摘要
目的合成针对肿瘤血管的新一代高效低毒抗癌物质CA-4,并改进工艺。方法本文以廉价的异香兰素为起始原料,经过Wittig等六步反应合成CA-4。结果所得产物经IR和1HNMR确证。结论原料廉价,工艺易过渡于工业生产。
引用
收藏
页码:210 / 211
页数:2
相关论文
共 10 条
[1]  
A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours develop ing various tissues and organs. Hori K,Saito S,Kubota K. British Journal of Cancer . 2002
[2]  
Synthesis of isocombretastatins A-C. Singh SB,Pettit GR. Synthetic Communications . 1987
[3]  
Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. Dark GG,H ill SA,Prise VE,et al. Cancer Research . 1997
[4]  
Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. Dark GG,H ill SA,Prise VE,et al. Cancer Research . 1997
[5]  
Structural requirements for the interaction of combretastatinswith tubulin: how important is the trimethoxy unit. Keira G,John A H,N icholas JL,et al. Organic and Biomolecular Chemistry . 2003
[6]  
Isolation structure and synthesis of Combretastatin C-1. Singh SB,Pettit GR. Journal of Organic Chemistry . 1985
[7]  
Synthesis and biological evaluation of aryl azide derivatives of Combretastatin A-4 as molecular probes for tubulin. Kevin GP,Maria PM,V ictorMV,et al. B ioorg Med Chem Lett . 2000
[8]  
Synthesis of natural (-)-combretastatin. Pettit GR,Singh SB. Journal of Organic Chemistry . 1985
[9]  
Synthesis ans structure-activity relationship of 2-am imobenzophenone derivatives as antim itotic agents. Liou JP,Chang CW,Song JS,et al. Journal of Medicinal Chemistry . 2002
[10]  
Designing therap ies that target tumour blood vessels. BerinagaM. Science . 1997