利用生物粘附技术提高萘哌地尔的生物利用度

被引：7

作者：

丁劲松

蒋学华

袁牧

机构：

[1] 湖南医科大学附属第二医院!湖南长沙,华西医科大学药学院!四川成都,贵阳医学院药学系!贵州贵阳

来源：

药学学报 | 2001年 / 05期

关键词：

萘哌地尔; 生物粘附; 药物动力学; 生物利用度;

D O I：

10.16438/j.0513-4870.2001.05.014

中图分类号：

R965 [实验药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的　为提高萘哌地尔生物利用度 ,制备生物粘附性萘哌地尔胶囊。方法　制备萘哌地尔胶囊、生物粘附胶囊I和II;比较两种生物粘附性胶囊与大鼠离体胃肠组织的粘附力 ;用自身对照方式单剂量分别给予家犬 3种胶囊 2 0 0mg ,比较 3种胶囊在家犬体内的药物动力学与生物利用度。结果　与普通胶囊相比 ,生物粘附性萘哌地尔胶囊I和II在家犬体内的血药峰浓度 (Cmax)下降 ,达峰时间 (Tmax)延迟 ,药时曲线下面积 (AUC0→∞)明显增加 ,两者为生物不等效制剂 ,与普通胶囊相比 ,萘哌地尔粘附胶囊I与II的生物利用度分别为 15 0 %± 14%和 15 4%± 2 3% ,两种生物粘附胶囊的药动学参数间无明显差异。结论　利用生物粘附技术能明显提高萘哌地尔的生物利用度

引用

页码：377 / 380

页数：4

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