他汀类药物对血管平滑肌细胞增殖的抑制机制

[1] HMG-CoA reductase inhibitors prevent migration human coronary smooth muscle cells through suppression of increase in oxidative stress. Yasunari K,Maeda K,Minami M,et al. Arteriosclerosis and Thrombosis . 2001

[2] Injury induces dedifferentiation of smooth muscle cells and increased matrix-degrading metalloproteinase activity in human saphenous vein. Johnson JL,van Eys GJ,Angelini GD,et al. Arteriosclerosis and Thrombosis . 2001

[3] Inhibition of small G proteins of the rho family by statins or clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II. Hausding M,Witteck A,Rodriguez Pascual F,et al. British Journal of Pharmacology . 2000

[4] 3-hydroxy-3methylglutaryl-CoA reductase inhibitors attenuate smooth muscle cells proliferation by preventing rho GTPase-induced down- regulation of p27 (Kipl). Laufs U,Marra D,Node K,et al. Journal of Biological Chemistry . 1999

[5] Differential effect of simvastatin on various signal transduction intermediates in cultured human smooth muscle cells. Negre AP,Van EM,Van LRE,et al. Biochemical Pharmacology . 2001

[6] Endothelial nitric oxide synthase is essential for the HMG-CoA reductase inhibitor cerivastatin to promote collateral growth in response to ischemia. Sata M,Nishimatsu H,Suzuki E,et al. The FASEB Journal . 2001

[7] Lipophilic statins induce apoptosis of human vascular smooth muscle cells. Guijarro C,Blanco Colio LM,Massy ZA,et al. Kidney International Supplement . 1999

[8] Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effect. Vincent L,Chen W,Hong L,et al. FEBS Letters . 2001

[9] Differences in the effects of the HMG-CoA reductase inhibitors on proliferation and viability of smooth muscle cells in culture. Sindermann JR,Fan L,Weigle KA,et al. Atherosclerosis . 2000

[10] Inhibitors of HMG-CoA reductase sensitize human smooth muscle cells to Fas-ligand and cytokine-induced cell death. Knapp AC,Huang J,Starling G,et al. Atherosclerosis . 2000

[1] HMG-CoA reductase inhibitors prevent migration human coronary smooth muscle cells through suppression of increase in oxidative stress. Yasunari K,Maeda K,Minami M,et al. Arteriosclerosis and Thrombosis . 2001

[2] Injury induces dedifferentiation of smooth muscle cells and increased matrix-degrading metalloproteinase activity in human saphenous vein. Johnson JL,van Eys GJ,Angelini GD,et al. Arteriosclerosis and Thrombosis . 2001

[3] Inhibition of small G proteins of the rho family by statins or clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II. Hausding M,Witteck A,Rodriguez Pascual F,et al. British Journal of Pharmacology . 2000

[4] 3-hydroxy-3methylglutaryl-CoA reductase inhibitors attenuate smooth muscle cells proliferation by preventing rho GTPase-induced down- regulation of p27 (Kipl). Laufs U,Marra D,Node K,et al. Journal of Biological Chemistry . 1999

[5] Differential effect of simvastatin on various signal transduction intermediates in cultured human smooth muscle cells. Negre AP,Van EM,Van LRE,et al. Biochemical Pharmacology . 2001

[6] Endothelial nitric oxide synthase is essential for the HMG-CoA reductase inhibitor cerivastatin to promote collateral growth in response to ischemia. Sata M,Nishimatsu H,Suzuki E,et al. The FASEB Journal . 2001

[7] Lipophilic statins induce apoptosis of human vascular smooth muscle cells. Guijarro C,Blanco Colio LM,Massy ZA,et al. Kidney International Supplement . 1999

[8] Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effect. Vincent L,Chen W,Hong L,et al. FEBS Letters . 2001

[9] Differences in the effects of the HMG-CoA reductase inhibitors on proliferation and viability of smooth muscle cells in culture. Sindermann JR,Fan L,Weigle KA,et al. Atherosclerosis . 2000

[10] Inhibitors of HMG-CoA reductase sensitize human smooth muscle cells to Fas-ligand and cytokine-induced cell death. Knapp AC,Huang J,Starling G,et al. Atherosclerosis . 2000