调节性T细胞在肿瘤免疫和肿瘤免疫治疗中的作用

被引：79

作者：

于益芝

曹雪涛

机构：

[1] 第二军医大学免疫学研究所医学免疫学国家重点实验室

来源：

中国肿瘤生物治疗杂志 | 2010年 / 17卷 / 01期

关键词：

调节性T细胞; 肿瘤; 免疫逃逸; 免疫治疗;

D O I：

暂无

中图分类号：

R730.5 [肿瘤治疗学];

学科分类号：

100214 [肿瘤学];

摘要：

肿瘤局部存在多种类型的免疫抑制性细胞,其中调节性T细胞(regulatoryT cell,Treg)在肿瘤的发生、发展过程中发挥着极为重要的作用。Treg通过多种机制抑制免疫效应细胞的功能,是肿瘤免疫逃逸的关键因素。这些机制包括分泌抑制性细胞因子抑制效应细胞功能、分泌颗粒酶和穿孔素杀伤效应细胞、干扰效应细胞的代谢功能,以及通过调控树突状细胞影响Treg的分化和增殖,等等。Treg的深入研究为肿瘤免疫治疗提供了新的思路,以Treg及相关免疫抑制性分子作为靶点,通过特异性或非特异性清除Treg、控制Treg的数量和功能等开展肿瘤免疫治疗具有良好的临床应用前景。

引用

页码：1 / 6

页数：6

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