肝窦内皮细胞与肝窦毛细血管化研究进展

被引：29

作者：

杨丽 ^{[1
]}

江宇泳 ^{[2
,3
]}

机构：

[1] 北京中医药大学

[2] 首都医科大学传染病研究所

[3] 北京地坛医院中西医结合二科

来源：

传染病信息 | 2010年 / 03期

关键词：

肝窦内皮细胞; 肝窦毛细血管化; 表型;

D O I：

暂无

中图分类号：

R512.6 [病毒性肝炎];

学科分类号：

100201 [内科学];

摘要：

肝窦内皮细胞具有开放的、没有横膈膜的窗孔,内皮下没有基底膜。这种结构有利于调控肝细胞与肝窦血液的物质交换。肝窦内皮细胞能分泌内皮素-1和一氧化氮,并通过窗孔的变化,对肝脏微循环进行调节,同时可分泌大量的形成基底膜的成分,在肝窦毛细血管化的过程中起主导作用。肝窦内皮细胞表型标志发生变化,Ⅷ因子相关抗原、CD44等表达增强,也是肝窦毛细血管化的重要标志。笔者对肝窦内皮细胞的结构及其在肝窦毛细血管化中的功能和表型变化进行综述。

引用

页码：183 / 186

页数：4

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