心血管系统内皮素B型受体研究进展

被引：9

作者：

韩宝石

盖鲁粤

机构：

[1] 中国人民解放军总医院心血管内科

来源：

医学综述 | 2008年 / 12期

关键词：

内皮素B型受体; 内皮素; 心血管疾病;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

100201 [内科学];

摘要：

内皮素是迄今所发现的体内最强的缩血管物质,其与不同亚型的膜受体(包括内皮素受体A(endothelin receptor A,ETA)、B及C)结合后,产生不同甚至相反的病理生理效应。ETB受体主要参与内皮素的清除、血管舒张、水盐平衡,调节细胞增殖或凋亡,似乎作为"保护性受体"发挥作用。在多种心血管疾病发生、发展过程中,由于ETB受体调节异常,这种保护作用被减弱甚至逆转。本文对ETB受体的分布、信号途径、调节方式的研究进展予以综述。

引用

页码：1799 / 1801

页数：3

共 11 条

[1]

Late-onset endothelin-A receptor blockade reduces podocyte injury in homozygous Ren-2 rats despite severe hypertension [J].

Opocensky, Martin ;

Kramer, Herbert J. ;

Backer, Angela ;

Vernerova, Zdenka ;

Eis, Vaclav ;

Cervenka, Ludek ;

Certikova Chabova, Vera ;

Tesar, Vladimir ;

Vaneckova, Ivana .

HYPERTENSION, 2006, 48 (05) :965-971

[2]

Upregulation of endothelin receptor B in human endothelial cells by low-density lipoproteins [J].

Muller, Gregor ;

Catar, Rusan A. ;

Niemann, Bernd ;

Barton, Matthias ;

Knels, Lilla ;

Wendel, Martina ;

Morawietz, Henning .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2006, 231 (06) :766-771

[3]

Enhanced response of pig coronary arteries to endothelin-1 after ischemia–reperfusion. Role of endothelin receptors; nitric oxide and prostanoids.[J].Belén Climent;Nuria Fernández;Elena Sanz;Ana Sánchez;Luis Monge;Angel Luis García-Villalón;Godofredo Diéguez.European Journal of Pharmacology.2005, 1

[4]

Immunolocalization of Endothelin-B Receptor in Mouse Intestinal Tract.[J].Satoshi Takizawa;Tsuyoshi Uchide;Takaharu Kozakai;Javier Adur;Jiexia Quan;Kaname Saida.Journal of Cardiovascular Pharmacology.2004,

[5]

Cellular localization of the endothelin receptor subtypes ETA and ETB in the rat heart and their differential expression in coronary arteries, veins, and capillaries [J].

Wendel-Wellner, M ;

Noll, T ;

König, P ;

Schmeck, J ;

Koch, T ;

Kummer, W .

HISTOCHEMISTRY AND CELL BIOLOGY, 2002, 118 (05) :361-369

[6]

Negative inotropic effects of angiotensin II, endothelin-1 and phenylephrine in indo-1 loaded adult mouse ventricular myocytes [J].

Sakurai, K ;

Norota, I ;

Tanaka, H ;

Kubota, I ;

Tomoike, H ;

Endoh, M .

LIFE SCIENCES, 2002, 70 (10) :1173-1184

[7]

Endothelin-1 synthesis and endothelin B receptor expression in human coronary artery smooth muscle cells and monocyte-derived macrophages is up-regulated by low density lipoproteins [J].

Haug, C ;

Schmid-Kotsas, A ;

Zorn, U ;

Schuett, S ;

Gross, HJ ;

Gruenert, A ;

Bachem, MG .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2001, 33 (09) :1701-1712

[8]

.[J].Manfred Lauth;Andreas H. Wagner;Marco Cattaruzza;Hans-Dieter Orzechowski;Martin Paul;Markus Hecker.Journal of Molecular Medicine.2000, 8

[9]

Endothelin-1 Attenuates ω3 Fatty Acid–Induced Apoptosis by Inhibition of Caspase 3.[J].Quy N. Diep;Hope D. Intengan;Ernesto L. Schiffrin.Hypertension: Journal of the American Heart Association.2000; 1, Part 2 Suppl

[10]

Myocardial effects ofETB receptor stimulation..Leite-Moreira AF;Br偄s-Silva C;Pedrosa C;.Rev Port Cardiol.2002, 09

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