中医药抗肿瘤研究的新靶点——microRNA

被引：14

作者：

王兵

侯炜

机构：

[1] 中国中医科学院广安门医院肿瘤科

来源：

肿瘤防治研究 | 2013年 / 12期

关键词：

microRNA; 中医; 中药; 肿瘤; 有效成分; 机制;

D O I：

暂无

中图分类号：

R273 [中医肿瘤科];

学科分类号：

100502 [中医临床基础];

摘要：

<正>0引言microRNA即微小RNA或者miRNA,是近年来发现的一类新型的内源性小分子非编码RNA,其与短链干扰RNA(short interfering RNA,siRNA)和PIWI蛋白-作用RNA(PIWI interacting RNA,piRNA)共同构成人体非编码小RNA的三个亚型。microRNA长度约为19～25个核苷酸,普遍存在于动物、植物、真菌等多细胞真核生物中,进化上高度保守。

引用

页码：1200 / 1203

页数：4

共 12 条

[1]

白藜芦醇通过下调microRNA-151表达抑制肝癌细胞株HepG2细胞活性的研究 [J].

徐凌 ;

王锋 ;

徐选福 ;

莫文辉 ;

黄银实 ;

王兴鹏 ;

郭传勇 .

上海交通大学学报(医学版), 2010, 30 (07) :774-778

[2]

延胡索总碱对人肝癌细胞系HepG2抑制作用及其对microRNA表达谱的影响 [J].

张国铎 ;

谢丽 ;

胡文静 ;

禹立霞 ;

钱晓萍 ;

刘宝瑞 .

南京中医药大学学报, 2009, 25 (03) :181-183+241

[3]

Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells[J] Wing Pui Tsang;Tim Tak Kwok The Journal of Nutritional Biochemistry 2010,

[4]

Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells[J] Esmerina Tili;Jean-Jacques Michaille;Hansjuerg Alder;Stefano Volinia;Dominique Delmas;Norbert Latruffe;Carlo M. Croce Biochemical Pharmacology 2010,

[5]

Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway[J] Jian Zhang;Tao Zhang;Xinyu Ti;Jieran Shi;Changgui Wu;Xinling Ren;Hong Yin Biochemical and Biophysical Research Communications 2010,

[6]

MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma[J] Changzheng Liu;Jia Yu;Shuangni Yu;Robert M. Lavker;Lei Cai;Wei Liu;Kegong Yang;Xiaodong He;Songsen Chen Journal of Hepatology 2010,

[7]

microRNA-143; down-regulated in osteosarcoma; promotes apoptosis andsuppresses tumorigenicity by targeting Bcl-2[J] Hao Zhang;Xiaobing Cai;Yang Wang;Hao Tang;Daki Tong;Fang Ji Oncology Reports 2010,

[8]

Curcumin promotes apoptosis in human lung adenocarcinoma cells throughmiR-186* signaling pathway[J] Jian Zhang;Yongping Du;Changgui Wu;Xinling Ren;Xinyu Ti;Jieran Shi;Feng Zhao;Hong Yin Oncology Reports 2010,

[9]

Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells[J] Jie Yang;Yunxin Cao;Jifeng Sun;Yong Zhang Medical Oncology 2010,

[10]

MicroRNAs in Cancer[J] Yong Sun Lee;Anindya Dutta Annual Review of Pathology: Mechanisms of Disease 2009,

← 1 2 →