脑肠肽、摄食调控与肥胖关系的研究进展

被引：17

作者：

刘艳华

李晓南

机构：

[1] 南京医科大学附属南京儿童医院儿童保健科

来源：

国际消化病杂志 | 2010年 / 30卷 / 06期

关键词：

脑肠肽; Ghrelin; 胰多肽; 肽YY; 胰高血糖素样肽-1; 胃泌酸调节素;

D O I：

暂无

中图分类号：

R589.2 [脂肪代谢障碍];

学科分类号：

100201 [内科学];

摘要：

单纯性肥胖的发生是能量代谢失衡的表现。脑肠肽包括促食欲肽和抑食欲肽,与摄食中枢的调节及能量摄入密切相关。Ghrelin是目前唯一可知的外周促食欲素,可以增加食欲,促进摄食。而另一些脑肠肽如胰多肽(PP)、肽YY(PYY)、胰高血糖素样肽-1(GLP-1)、胃泌酸调节素(OXM)的作用主要为抑制摄食。两类激素通过食欲调节中枢相互作用,对肥胖的发生发展产生重要的影响。研究并阐明脑肠肽激素在胃肠道中的分布、代谢与食欲调控机制,有可能成为未来肥胖预防和治疗的靶标。

引用

页码：357 / 360

页数：4

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