尖锐湿疣的免疫学发病机制

被引:28
作者
郭红卫
机构
[1] 广东医学院皮肤性病研究所
关键词
尖锐湿疣; Th1/Th2平衡; 克隆漂移;
D O I
暂无
中图分类号
R752.53 [];
学科分类号
摘要
尖锐湿疣患者Th1型细胞因子水平普遍降低 ,Th2型细胞因子水平相对普遍增高 ,Th1细胞活动处于弱势 ,Th2细胞活动相对强势 ,免疫反应由病毒激发的Th1介导的细胞免疫应答倾向于Th2亚群细胞介导的免疫应答 ,从而不能有效进行细胞免疫应答清除病毒。尖锐湿疣患者免疫反应向Th2方向漂移可能是人类乳头瘤病毒发生免疫逃逸的一种机制。根据机体Th细胞漂移状况 ,设法使免疫反应由Th2型向Th1型逆转 ,调整Th1/Th2平衡 ,据此设计相应的治疗方案 ,将可能辅助临床治疗尖锐湿疣。
引用
收藏
页码:296 / 299
页数:4
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