癌症治疗对海马神经元生成的影响及其与认知功能和抑郁症间的关系

被引：4

作者：

张丽虹 ^{[1
,2
]}

江沛 ^{[1
,2
]}

李焕德 ^{[1
]}

蔡骅琳 ^{[1
]}

朱文叶 ^{[1
,2
]}

党瑞丽 ^{[1
,2
]}

机构：

[1] 中南大学湘雅二医院临床药学研究室

[2] 中南大学药学院

来源：

中南药学 | 2015年 / 13卷 / 02期

关键词：

癌症治疗; 成人海马神经元生成; 认知障碍; 抑郁;

D O I：

暂无

中图分类号：

R730.5 [肿瘤治疗学];

学科分类号：

100214 [肿瘤学];

摘要：

海马区齿状回颗粒下层是大脑神经元生成的主要区域,动物成年后神经干细胞仍不断的增殖和变异,形成新的神经元。成人海马神经元生成与空间意识、长期记忆、情感及情绪等功能相关。癌症治疗的目的是为了减少肿瘤细胞的分裂,然而,异常细胞分裂被中断的同时也抑制了成年神经干细胞的增殖和海马神经元的生成。癌症患者在治疗过程中常伴随着记忆功能的衰退及抑郁症状的出现。因此,本文主要综述癌症治疗对成人海马神经元生成的影响及与伴随出现的认知和情绪障碍间的潜在联系。

引用

页码：162 / 165

页数：4

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