miR-208和miR-499与心血管病研究进展

被引：4

作者：

陈耽

李骊华

机构：

[1] 重庆医科大学附属第一医院心血管科

来源：

中国老年学杂志 | 2015年 / 35卷 / 08期

关键词：

miR-208; miR-499; 心血管病;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

100201 [内科学];

摘要：

<正>microRNA(miRNA)是一类由20～25个核苷酸组成的在进化上高度保守的内源性小分子单链非编码RNA。主要通过与靶mRNA的3'-非编码区(3'-UTR)的特异性序列碱基互补配对结合,产生转录后抑制,从而调控基因的表达〔1〕。miRNA在高等生物生命活动中扮演重要角色,参与生物细胞增殖、分化、免疫、应激、凋亡、癌变等多种生命过程,并在肿瘤发生及心血管病等各种疾病中起到至关重要的作用。

引用

收藏

页码：2270 / 2273

页数：4

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