新型抗血小板药物研究进展

被引：9

作者：

王劲

杨天燕

张靖贤

机构：

[1] 广西医科大学第一附属医院药剂科

来源：

广西医学 | 2013年 / 35卷 / 02期

关键词：

抗血栓药物; 抗血小板药物; 血栓烷受体拮抗剂; 嘌呤能受体拮抗剂; 蛋白酶激活受体拮抗剂;

D O I：

暂无

中图分类号：

R972 [心血管系统药物];

学科分类号：

1007 ;

摘要：

动、静脉栓塞引发的血栓病发病率与死亡率多年来一直居高不下,因而抗血小板药物开发是心血管药物研发的热点领域。抗血栓药物治疗的目的在于预防高危患者的病理性血栓形成,防止已形成血栓的患者体内的血凝块扩展或发生栓塞。本文主要概述研发新型抗血栓药物的必要性,新上市与目前正在进行Ⅱ期或Ⅲ期临床试验的抗血小板药物的研究进展。

引用

页码：231 / 234

页数：4

共 12 条

[1] 血栓性疾病已成为威胁人类健康和生命的重要疾病 [J].

袁桂清 .

中华检验医学杂志, 2004, (08)

[2]

Critical appraisal of ticagrelor in the management of acute coronary syndrome[J] . James Nawarskas,Snowden.Therapeutics and Clinical Risk Management . 2011 (defa)

[3]

Cangrelor: a review on its mechanism of action and clinical development[J] . Ferreiro,Ueno,Angiolillo.Expert Review of Cardiovascular Therapy . 2009 (10)

[4]

Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study[J] . Richard C Becker,David J Moliterno,Lisa K Jennings,Karen S Pieper,Jinglan Pei,Alan Niederman,Khaled M Ziada,Gail Berman,John Strony,Diane Joseph,Kenneth W Mahaffey,Frans Van de Werf,Enrico Veltri,Robert A Harrington.The Lancet . 2009 (9667)

[5]

Prevalence of persistent platelet reactivity despite use of aspirin: A systematic review[J] . Marcel M.C. Hovens,Jaapjan D. Snoep,Jeroen C.J. Eikenboom,Johanna G. van der Bom,Bart J.A. Mertens,Menno V. Huisman.American Heart Journal . 2007 (2)

[6] Variable response to clopidogrel in patients with coronary artery disease [J].

Geisler, Tobias ;

Gawaz, Meinrad .

SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2007, 33 (02) :196-202

[7] AZD6140 [J].

Tantry, Udaya S. ;

Bliden, Kevin P. ;

Gurbel, Paul A. .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2007, 16 (02) :225-229

[8] Aspirin resistance [J].

Hankey, GJ ;

Eikelboom, J .

LANCET, 2006, 367 (9510) :606-617

[9]

Randomized Comparison of Prasugrel (CS-747, LY640315), a Novel Thienopyridine P2Y12 Antagonist, With Clopidogrel in Percutaneous Coronary Intervention: Results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)–TIMI 26 Trial[J] . Stephen D. Wiviott,Elliott M. Antman,Kenneth J. Winters,Govinda Weerakkody,Sabina A. Murphy,Bruce D. Behounek,Robert J. Carney,Charles Lazzam,Raymond G. McKay,Carolyn H. McCabe,Eugene Braunwald.Circulation . 2005 (25)

[10]

Clopidogrel and Ticlopidine: P2Y12 Adenosine Diphosphate-Receptor Antagonists for the Prevention of Atherothrombosis[J] . Pierre Savi,Jean-Marc Herbert.Semin Thromb Hemost . 2005 (02)

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