直接经皮冠状动脉介入治疗患者血浆高敏C反应蛋白水平与心肌灌注的相关性研究

被引：8

作者：

张宇晨

贾三庆

王雷

李虹伟

机构：

[1] 首都医科大学附属北京友谊医院心血管疾病诊治研究中心

来源：

中华心血管病杂志 | 2006年 / 05期

关键词：

心肌梗塞; 血管成形术,经腔,经皮冠状动脉; C反应蛋白; 心肌再灌注;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

摘要：

目的分析急性心肌梗死患者入院时血浆高敏C反应蛋白(hs-CRP)水平和直接经皮冠状动脉介入治疗(PCI)术后心肌灌注的关系。方法选择2001年10月—2004年12月在我院住院治疗的首发急性心肌梗死患者197例,其中男154例,女43例,平均年龄(60.94±11.62)岁。TIMI心肌灌注分级(TIMImyocardialperfusiongrade,TMPG)0～1级患者为Ⅰ组(n=39,19.8%),TMPG2～3级患者为Ⅱ组(n=158,80.2%)。所有入选患者第一次空腹静脉血检测甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、hs-CRP;并在发病后2、6、10、12、16、24、48、72h静脉抽血测定肌酸激酶同工酶;发病48h内超声心动图测定左室射血分数值。结果两组患者之间年龄、性别、病史差异无统计学意义。Ⅰ组与Ⅱ组比较,入院时血浆hs-CRP水平差异有统计学意义[(8.29±4.75)mg/L比(6.38±4.73)mg/L,P=0.026]。肌酸激酶峰值[(3017.85±1901.19)U/L比(2701.41±1992.97)U/L]、肌酸激酶同工酶峰值[(442.37±333.29)U/L比(355.91±287.99)U/L]、发病到球囊扩张的时间两组间差异无统计学意义。结论hs-CRP是炎性反应的标志物,反映了斑块局部的稳定性;直接PCI患者血浆hs-CRP水平是PCI术后心肌再灌注不良的重要影响因素。

引用

页码：422 / 424

页数：3

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