STAT4多态性与自身免疫性疾病相关性研究进展

被引:4
作者
张薇
杨林花
机构
[1] 山西医科大学第二医院血液科
关键词
自身免疫性疾病; 细胞分化; 自身免疫病; STAT4; 单核苷酸多态性;
D O I
暂无
中图分类号
R392.2 [免疫遗传学];
学科分类号
071007 ;
摘要
<正>自身免疫性疾病是机体对自身成分发生免疫应答而导致的疾病状态,其基本特征是自身应答性T淋巴细胞或自身抗体造成相应的组织细胞损伤或功能障碍,血液中可检测到高效价的自身应答性T淋巴细胞和/或自身抗体,且病情的转归与自身免疫应答的强度密切相关。T辅助细胞1型(T-helper cell type 1,Th1)、Th17细胞功能失调可诱导多种自身免疫性疾病的发生[1]。信号转导和转录激活子4(Signal transducer and
引用
收藏
页码:141 / 144
页数:4
相关论文
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