糖尿病与认知功能障碍相关性的研究进展

被引:29
作者
杨雪
陈奕錡
袁慧娟
机构
[1] 郑州大学人民医院内分泌代谢科
关键词
糖尿病,1型; 糖尿病,2型; 认知功能障碍;
D O I
暂无
中图分类号
R587.1 [糖尿病]; R749.2 [躯体疾病伴发精神障碍];
学科分类号
100201 [内科学]; 100204 [神经病学];
摘要
随着人口的老龄化和糖尿病患病率攀升,糖尿病中枢神经系统并发症越来越受到关注。T1DM和T2DM均可能影响大脑体积及脑区之间功能联系,影响执行能力、记忆力、注意力、智力等多方面认知功能,但两者中枢神经病变异同,目前研究尚无定论,机制仍未阐明。多元醇通路、AGEs、氧化应激、一氧化氮与自噬、神经炎症、反复低血糖、血管病变、IR或分泌不足、雌激素等多种因素可能参与神经元坏死、凋亡等,增加痴呆发生风险。
引用
收藏
页码:1144 / 1147
页数:4
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