黄酮抑制血小板聚集及其构效的研究

被引：9

作者：

郭一萌 ^{[1
]}

郭春梅 ^{[2
]}

刘淑清 ^{[1
]}

鱼红闪 ^{[3
]}

孙明忠 ^{[2
]}

机构：

[1] 大连医科大学生物化学与分子生物学教研室

[2] 大连医科大学生物技术系

[3] 大连工业大学生物工程学院

来源：

大连医科大学学报 | 2012年 / 34卷 / 05期

关键词：

黄酮类化合物; 血小板聚集; 结构; 功能;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

[目的]比较8种黄酮对血小板聚集的抑制作用并探讨其构效关系。[方法]采用体外实验方法,测定黄酮类化合物对ADP诱导大鼠血小板聚集的抑制作用,并计算其抑制率。[结果]槲皮素、芦丁、异槲皮素、橙皮素、柚皮素、橙皮苷、柚皮苷和淫羊藿苷对血小板聚集的抑制率分别为(68.33±2.43)%、(55.34±2.09)%、(52.27±4.65)%、(50.80±7.03)%、(33.07±2.09)%、(31.28±4.65)%、(22.91±1.68)%和(20.94±3.20)%,8种黄酮类化合物对血小板聚集均呈现抑制作用。与对照组(不加黄酮类化合物)相比,差异均有显著性意义(P<0.05)。[结论]黄酮类化合物对血小板聚集有明显抑制作用,A环C7位和C环C3位的羟基是该类化合物抑制血小板聚集发挥作用的重要功能基团。

引用

页码：424 / 427

页数：4

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