IL-27增强TNF-α介导上调的炎症因子的表达

被引：7

作者：

邱怀娜

查贺飞

曲佳乐

王梅

冯源发

黄俊

杨权

机构：

[1] 广州医科大学病原生物学与免疫学教研室

来源：

现代生物医学进展 | 2017年 / 17卷 / 23期

基金：

广东省科技计划;

关键词：

血管炎症; 细胞因子; 趋化因子; 人冠状动脉内皮细胞;

D O I：

10.13241/j.cnki.pmb.2017.23.003

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

100201 [内科学];

摘要：

目的:动脉粥样硬化是慢性炎症疾病,免疫细胞及炎症因子在其发病过程中起重要调节作用。本研究在于探讨IL-27对血管内皮细胞的直接作用。方法:采用ELISA方法,研究IL-27和TNF-α对人冠状动脉内皮细胞产生炎症相关细胞因子和趋化因子的作用。结果:IL-27显著增强TNF-α介导上调的炎症相关细胞因子IL-6和趋化因子CCL5的表达。IL-6和CCL5的表达受特异性信号分子抑制剂显著抑制。结论:人冠状动脉内皮细胞诱导释放IL-6和CCL5可能受JNK,p38MAPK和NF-κB通路差异调控。这些结果为阐明IL-27与TNF-α在动脉粥样硬化血管炎症发生中的作用提供重要生物化学基础。

引用

页码：4412 / 4415

页数：4

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