神经胶质瘤患者血浆外泌体lncRNA LINC00511的表达及意义

被引：7

作者：

王博

王亚周

王凯

靳腾龙

崔丙周

贺艳阳

机构：

[1] 郑州人民医院神经外科

来源：

中国实用神经疾病杂志 | 2019年 / 14期

关键词：

神经胶质瘤; 外泌体; lncRNA LINC00511; 临床病理参数; 回归分析; 预后;

D O I：

暂无

中图分类号：

R739.41 [颅内肿瘤及脑肿瘤];

学科分类号：

100115 [医学神经生物学];

摘要：

目的探讨神经胶质瘤患者血浆外泌体长链非编码RNA LINC00511(lncRNA LINC00511)的表达水平及临床意义。方法选取2012-01-2016-04郑州人民医院收治的82例神经胶质瘤患者为研究对象,选取同期80例体检健康者为对照组,采用实时荧光定量PCR(qRT-PCR)检测所有受试者血浆外泌体lncRNA LINC00511水平,观察受试者血浆外泌体lncRNA LINC00511表达情况,并探讨其与临床病理参数和预后的关系。结果 WHOⅢ～Ⅳ级、Ⅰ～Ⅱ级神经胶质瘤患者血浆外泌体lncRNA LINC00511水平明显高于对照组(P<0.05),Ⅲ～Ⅳ级患者高于Ⅰ～Ⅱ级患者(P<0.05);lncRNA LINC00511与患者WHO分级、KPS评分相关(P<0.05);lncRNA LINC00511高表达组生存率为34.09%,明显低于低表达组的65.79%(P<0.05),高表达组中位数生存时间为(42.00±3.60)个月,明显低于低表达组的(51.00±6.07)个月(P<0.05);多因素COX比例分析显示,高表达水平的lncRNA LINC00511、高WHO分级及KPS评分≤80分是神经胶质瘤患者预后不良的危险因素。结论 lncRNA LINC00511在神经胶质瘤患者血浆外泌体中表达上调,并与临床病理特征及预后密切相关。

引用

页码：1548 / 1553

页数：6

共 15 条

[1]

Analysis of the miRNA–mRNA–lncRNA network in human estrogen receptor-positive and estrogen receptor-negative breast cancer based on TCGA data[J] Bin Xiao;Weiyun Zhang;Lidan Chen;Jianfeng Hang;Lizhi Wang;Rong Zhang;Yang Liao;Jianyun Chen;Qiang Ma;Zhaohui Sun;Linhai Li Gene 2018,

[2]

LINC 00511 interacts with miR‐765 and modulates tongue squamous cell carcinoma progression by targeting LAMC 2[J] Junhai Ding;Changxi Yang;Sen Yang Journal of Oral Pathology & Medicine 2018,

[3]

Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587[J] Javier Figueroa;Lynette M. Phillips;Tal Shahar;Anwar Hossain;Joy Gumin;Hoon Kim;Andrew J. Bean;George A. Calin;Juan Fueyo;Edgar T. Walters;Raghu Kalluri;Roel G. Verhaak;Frederick F. Lang Cancer Research 2017,

[4]

ER –mitochondria contacts control surface glycan expression and sensitivity to killer lymphocytes in glioma stem‐like cells[J] Esen Yonca Bassoy;Atsuko Kasahara;Valentina Chiusolo;Guillaume Jacquemin;Emma Boydell;Sebastian Zamorano;Cristina Riccadonna;Serena Pellegatta;Nicolas Hulo;Valérie Dutoit;Madiha Derouazi;Pierre Yves Dietrich;Paul R Walker;Denis Martinvalet The EMBO Journal 2017,

[5]

Long non-coding RNA ZFAS1 is an unfavourable prognostic factor and promotes glioma cell progression by activation of the Notch signaling pathway[J] Kai Gao;Zhiwu Ji;Kun She;Qingyan Yang;Lianbin Shao Biomedicine & Pharmacotherapy 2017,

[6]

PS2 - 195 Integrating Molecular Workings into the World Health Organization (WHO) Classification of Tumours of the Central Nervous System: A Survey from the Neuro-Oncology Community[J] R. Nejad;D.N. Louis;K. Aldape;G. Zadeh Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 2016,

[7]

Improve Glioblastoma Multiforme Prognosis Prediction by Using Feature Selection and Multiple Kernel Learning[J] Ya Zhang;Ao Li;Chen Peng;Minghui Wang IEEE/ACM Transactions on Computational Biology an 2016,

[8]

Expression of the galectin-9‑Tim-3 pathway in glioma tissues is associatedwith the clinical manifestations of glioma[J] Zengjin Liu;Huamin Han;Xin He;Shouwei Li;Chenxing Wu;Chunjiang Yu;Shengdian Wang Oncology Letters 2016,

[9]

The Nuclear Receptor; RORγ; Regulates Pathways Necessary for Breast Cancer Metastasis[J] Tae Gyu Oh;Shu-Ching M. Wang;Bipul R. Acharya;Joel M. Goode;J. Dinny Graham;Christine L. Clarke;Alpha S. Yap;George E.O. Muscat EBioMedicine 2016,

[10]

A novel cell cycle-associated lncRNA; HOXA11-AS; is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma[J] Qixue Wang;Junxia Zhang;Yanwei Liu;Wei Zhang;Junhu Zhou;Ran Duan;Peiyu Pu;Chunsheng Kang;Lei Han Cancer Letters 2016,

← 1 2 →