癫发病机制研究进展

被引:3
作者
陈婵娟
姜婷
房雅娜
肖波
机构
[1] 中南大学湘雅医院神经内科
关键词
癫; 发病机制; 离子通道; 神经递质受体; 突触重塑; 神经胶质细胞; 皮质发育;
D O I
暂无
中图分类号
R742.1 [癫痫];
学科分类号
1002 ;
摘要
癫的发作与大脑神经元异常同步放电有关,是影响人类健康的一大类疾患。本文综合国内外最新研究进展,从离子通道、神经递质受体、突触重塑、神经胶质细胞及皮质发育多方面探讨癫发病机制,以期对癫的形成有进一步认识。
引用
收藏
页码:265 / 269+279 +279
页数:6
相关论文
共 6 条
[1]   Functional analysis of novel KCNQ2 and KCNQ3 gene variants found in a large pedigree with benign familial neonatal convulsions (BFNC) [J].
Bassi, MT ;
Balottin, U ;
Panzeri, C ;
Piccinelli, P ;
Castaldo, P ;
Barrese, V ;
Soldovieri, MV ;
Miceli, F ;
Colombo, M ;
Bresolin, N ;
Borgatti, R ;
Taglialatela, M .
NEUROGENETICS, 2005, 6 (04) :185-193
[2]   Ionotropic and metabotropic glutamate receptor structure and pharmacology [J].
Kew, JNC ;
Kemp, JA .
PSYCHOPHARMACOLOGY, 2005, 179 (01) :4-29
[3]   A novel KCNQ2 K+ channel mutation in benign neonatal convulsions and centrotemporal spikes [J].
Coppola, G ;
Castaldo, P ;
del Giudice, EM ;
Bellini, G ;
Galasso, F ;
Soldovieri, MV ;
Anzalone, L ;
Sferro, C ;
Annuniziato, L ;
Taglialatela, M .
NEUROLOGY, 2003, 61 (01) :131-134
[4]   A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21-q33 [J].
Baulac, S ;
Gourfinkel-An, I ;
Picard, F ;
Rosenberg-Bourgin, M ;
Prud'homme, JF ;
Baulac, M ;
Brice, A ;
LeGuern, E .
AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (04) :1078-1085
[5]  
Autosomal Dominant Nocturnal Frontal-Lobe Epilepsy: Genetic Heterogeneity and Evidence for a Second Locus at 15q24[J] . H.A. Phillips,I.E. Scheffer,K.M. Crossland,K.P. Bhatia,D.R. Fish,C.D. Marsden,S.J.L. Howell,J.B.P. Stephenson,J. Tolmie,G. Plazzi,O. Eeg-Olofsson,R. Singh,I. Lopes-Cendes,E. Andermann,F. Andermann,S.F. Berkovic,J.C. Mulley.The American Journal of Human Genetics . 1998 (4)
[6]  
Both Doublecortin and Doublecortin-like Kinase Play a Role in Cortical Interneuron Migration .2 FRIOCOURT G,LI U JS,ANTYPA M,et al. J Neurosci . 2007