他汀类药物的多效性

被引:4
作者
王雅锋
苏洪亮
机构
[1] 西双版纳傣族自治州人民医院内一科
关键词
他汀类药物; 多效性; 降低胆固醇; 改善内皮舒张功能; 稳定动脉粥样硬化斑块;
D O I
暂无
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
他汀类药物为3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂,最初用于临床是由于其降低胆固醇的作用,随着临床实践及科学研究的不断深入,发现他汀类药物还具有抗炎、改善内皮舒张功能、抗氧化、降压、稳定动脉粥样硬化斑块等作用。他汀类药物的上述作用明显降低了心脑血管疾病发生率及病死率,提高了心脑血管疾病患者的生活质量,改善了心脑血管疾病患者的预后,引起了临床医师及科研工作者的广泛关注。
引用
收藏
页码:2188 / 2190
页数:3
相关论文
共 9 条
[1]  
Pharmacological approaches to improve endothelial repair mechanisms[J] . Besler,Doerries,Giannotti,Lüscher,Landmesser.Expert Review of Cardiovascular Therapy . 2008 (8)
[2]   Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model [J].
Iwakiri, Kentaro ;
Oda, Yutaka ;
Kaneshiro, Yasunori ;
Iwaki, Hiroyoshi ;
Masada, Toshiaki ;
Kobayashi, Akio ;
Asada, Akira ;
Takaoka, Kunio .
JOURNAL OF ORTHOPAEDIC SCIENCE, 2008, 13 (05) :463-468
[3]   Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2 [J].
Xu, S. Z. ;
Zhong, W. ;
Watson, N. M. ;
Dickerson, E. ;
Wake, J. D. ;
Lindow, S. W. ;
Newton, C. J. ;
Atkin, S. L. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2008, 6 (04) :692-700
[4]  
Coronary reactivity, homocysteine and methylenetetrahydrofolate reductase gene variation in young men during pravastatin therapy[J] . Vascular Pharmacology . 2007 (2)
[5]   Pitavastatin restores vascular dysfunction in insulin-resistant state by inhibiting NAD(P)H oxidase activity and uncoupled endothelial nitric oxide synthase-dependent superoxide production [J].
Shinozaki, Kazuya ;
Nishio, Yoshihiko ;
Ayajiki, Kazuhide ;
Yoshida, Yuichi ;
Masada, Masahiro ;
Kashiwagi, Atsunori ;
Okamura, Tomio .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2007, 49 (03) :122-130
[6]   A combination of statins and beta-blockers is independently associated with a reduction in the incidence of perioperative mortality and nonfatal myocardial infarction in patients undergoing abdominal aortic aneurysm surgery [J].
Kertai, MD ;
Boersma, E ;
Westerhout, CM ;
Klein, J ;
van Urk, H ;
Bax, JJ ;
Roelandt, JRTC ;
Poldermans, D .
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 2004, 28 (04) :343-352
[7]   Pravastatin has an additional depressor effect in patients undergoing long-term treatment with antihypertensive drugs [J].
Ikeda, T ;
Sakurai, J ;
Nakayama, D ;
Takahashi, Y ;
Matsuo, K ;
Shibuya, Y ;
Gomi, T ;
Moriya, H ;
Kobayashi, S .
AMERICAN JOURNAL OF HYPERTENSION, 2004, 17 (06) :502-506
[8]  
Simvastatin in primary biliary cirrhosis: effects on serum lipids and distinct disease markers[J] . Journal of Hepatology . 2002 (4)
[9]   Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts [J].
Lefer, AM ;
Campbell, B ;
Shin, YK ;
Scalia, R ;
Hayward, R ;
Lefer, DJ .
CIRCULATION, 1999, 100 (02) :178-184