血清胸苷激酶1对Ⅳ期结肠癌化疗疗效评估的价值

被引:5
作者
夏莹子
刘永萍
齐秋锋
朱明
张亚平
凌扬
机构
[1] 苏州大学附属常州肿瘤医院肿瘤实验室及肿瘤内科
关键词
血清胸苷激酶1; 结肠癌; 临床疗效;
D O I
暂无
中图分类号
R735.35 [];
学科分类号
摘要
目的分析血清胸苷激酶1(S-TK1)对Ⅳ期结肠癌患者化疗疗效评估的价值。方法采用免疫印迹增强化学发光法检测61例Ⅳ期结肠癌患者和41例健康体检者的S-TK1水平。结果Ⅳ期结肠癌患者的S-TK1水平[(3.47±2.33)pmol·L-1]高于健康体检者[(1.07±0.87)pmol·L-1](P<0.05);S-TK1水平与Ⅳ期结肠癌患者的ECOG评分有关(P<0.05);与化疗前比较,化疗后获得疾病控制的Ⅳ期结肠癌患者S-TK1水平呈下降趋势(P<0.05),PD患者S-TK1水平明显上升(P<0.05)。结论监测S-TK1水平对预测Ⅳ期结肠癌的化疗疗效具有一定的价值。
引用
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页码:6 / 8
页数:3
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