基质金属蛋白酶在心肌缺血再灌注损伤中的作用

被引：4

作者：

黄健男

张瑞岩

机构：

[1] 上海交通大学医学院附属瑞金医院

来源：

现代生物医学进展 | 2011年 / 11卷 / 13期

关键词：

基质金属蛋白酶; 缺血再灌注; 心肌损伤;

D O I：

10.13241/j.cnki.pmb.2011.13.020

中图分类号：

R542.22 [];

学科分类号：

1002 ; 100201 ;

摘要：

肌缺血再灌注损伤是指缺血心肌组织在恢复血流供给后,其细胞代谢功能障碍及结构破坏反而加重的现象,主要表现在心肌收缩与舒张功能障碍、血管内皮功能障碍、微循环血流紊乱、细胞代谢失调、电解质平衡紊乱、细胞凋亡与坏死等,并伴随着氧自由基的大量产生和毒性损伤以及炎症反应的激活,是一个极其复杂的病理过程。基质金属蛋白酶(MMPs)及其组织抑制物(TIMPs)是心肌组织中多种细胞分泌的内源性细胞因子,其作用涵盖了细胞外基质降解、炎症反应激活、调节血管功能、影响细胞凋亡与存活等众多病理生理过程,而这些过程均在心肌缺血再灌注损伤中发挥着重要的作用。

引用

页码：2584 / 2586

页数：3

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