聚丙交酯/聚乙二醇多嵌段共聚物的合成及其性能

A series of multiblock copolymers of PLLA\|PEG(PLE) with high molecular weight were synthesized by coupling PLLA\|PEG\|PLLA triblock copolymers with succinic anhydride in the presence of ( N,N\| dimethylamino) pyridine(DMAP) and dicyclohexylcarbodimide (DCC).The results of the viscometry measurement,GPC and 1H\|NMR,elucidated that multiblock PLE copolymers with high content of short PEG segments( M n=2000) had been successfully obtained.The crystallinity of the copolymers was investigated by X\|ray diffraction.Mechanical testing showed that multiblock copolymers had relatively high tensile strength and large elongation.In a word,the measurements showed that the multiblock PLE copolymers had high content of short PEG segments( M n=2000),high molecular weight( M w～100,000),excellent hydrophilicity and mechanical properties.The results of cells cultured on the multiblock PLE copolymer indicated that it might be suitable to be utilized as cell scaffold for tissue engineering.