支气管哮喘发病机制的新认识

被引：52

作者：

费凡

吉宁飞

黄茂

机构：

[1] 南京医科大学第一附属医院呼吸与危重症医学科

来源：

国际呼吸杂志 | 2018年 / 38卷 / 12期

关键词：

支气管哮喘; 发病机制;

D O I：

暂无

中图分类号：

R562.25 [];

学科分类号：

摘要：

支气管哮喘(简称哮喘)是一种多因素引起的以可逆性气道阻塞、气道高反应性和气道炎症为特征的异质性疾病。哮喘的病因和发病机制复杂,因此本文将从哮喘的遗传学、表观遗传学方面探讨,同时结合气道炎症、气道重塑和气道高反应性进行阐述。

引用

收藏

相关论文

共 16 条

[1]

Raised interferon‐β; type 3 interferon and interferon‐stimulated genes – evidence of innate immune activation in neutrophilic asthma.[J].J. da Silva;C. Hilzendeger;C. Moermans;F. Schleich;M. Henket;T. Kebadze;P. Mallia;M. R. Edwards;S. L. Johnston;R. Louis.Clinical & Experimental Allergy.2017, 3

[2]

Clinical approaches towards asthma and chronic obstructive pulmonary disease based on the heterogeneity of disease pathogenesis [J].

Hizawa, N. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2016, 46 (05) :678-687

[3]

Ten-eleven translocation 1 (TET1) methylation is associated with childhood asthma and traffic-related air pollution [J].

Somineni, Hari K. ;

Zhang, Xue ;

Myers, Jocelyn M. Biagini ;

Kovacic, Melinda Butsch ;

Ulm, Ashley ;

Jurcak, Noelle ;

Ryan, Patrick H. ;

Hershey, Gurjit K. Khurana ;

Ji, Hong .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 137 (03) :797-+

[4]

Molecular phenotyping and biomarker development: are we on our way towards targeted therapy for severe asthma? [J].

De Ferrari, Laura ;

Chiappori, Alessandra ;

Bagnasco, Diego ;

Riccio, Anna Maria ;

Passalacqua, Giovanni ;

Canonica, Giorgio Walter .

EXPERT REVIEW OF RESPIRATORY MEDICINE, 2016, 10 (01) :29-38

[5]

Heterogeneity of Lower Airway Inflammation in Children With Severe-Persistent Asthma [J].

O'Brien, Caitlin E. ;

Tsirilakis, Kalliope ;

Santiago, Maria Teresa ;

Goldman, David L. ;

Vicencio, Alfin G. .

PEDIATRIC PULMONOLOGY, 2015, 50 (12) :1200-1204

[6]

Pathobiology of Severe Asthma.[J].Humberto E. Trejo Bittar;Samuel A. Yousem;Sally E. Wenzel.Annual Review of Pathology: Mechanisms of Disease.2015, 1

[7]

Heterogeneity of phenotypes in severe asthmatics. The Belgian Severe Asthma Registry (BSAR) [J].

Schleich, F. ;

Brusselle, G. ;

Louis, R. ;

Vandenplas, O. ;

Michils, A. ;

Pilette, C. ;

Peche, R. ;

Manise, M. ;

Joos, G. .

RESPIRATORY MEDICINE, 2014, 108 (12) :1723-1732

[8]

Childhood asthma and obesity-what is the true link? [J].

Permaul, Perdita ;

Kanchongkittiphon, Watcharoot ;

Phipatanakul, Wanda .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2014, 113 (03) :244-246

[9]

Passive Smoking Impairs Histone Deacetylase-2 in Children With Severe Asthma [J].

Kobayashi, Yoshiki ;

Bossley, Cara ;

Gupta, Atul ;

Akashi, Kenichi ;

Tsartsali, Lemonia ;

Mercado, Nicolas ;

Barnes, Peter J. ;

Bush, Andrew ;

Ito, Kazuhiro .

CHEST, 2014, 145 (02) :305-312

[10]

Passive Smoking Induces Leukotriene Production in Children: Influence of Asthma [J].

Hernandez-Alvidrez, Elizabeth ;

Alba-Reyes, Georgina ;

Munoz-Cedillo, Bernardo C. ;

Luis Arreola-Ramirez, Jose ;

Yuriko Furuya, Maria Elena ;

Becerril-Angeles, Martin ;

Vargas, Mario H. .

JOURNAL OF ASTHMA, 2013, 50 (04) :347-353