Kv7钾离子通道在血管平滑肌中的表达及功能

被引：6

作者：

张璇

刘灵

焦晓翠

陈兴娟

贾占峰

杲海霞

张海林

机构：

[1] 河北医科大学药理学教研室

来源：

中国药理学通报 | 2013年 / 04期

关键词：

Kv7钾离子通道; KCNQ基因; 血管平滑肌; 高血压; 瑞替加滨; XE991;

D O I：

暂无

中图分类号：

R331 [血液与循环生理];

学科分类号：

100123 [人体微生态学];

摘要：

KCNQ基因(KCNQ1～5)编码的电压门控型Kv7钾离子通道广泛存在于心肌细胞(Kv 7.1)和神经系统(Kv 7.2～7.5),在调节神经兴奋性和心肌动作电位方面发挥着重要的作用。近来,KCNQ基因被发现高表达于血管平滑肌细胞并在调节血管收缩中发挥着重要的作用。该文将对目前Kv7钾离子通道在血管平滑肌细胞中的表达、功能及Kv7钾离子通道开放剂对高血压的潜在治疗作用的证据进行总结。

引用

页码：457 / 460

页数：4

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