替吉奥胶囊联合紫杉醇治疗晚期胃癌28例临床观察

被引：10

作者：

周恒根

倪敬中

刘兰芳

程燕

李亚莉

李华年

机构：

[1] 邳州市人民医院肿瘤科

来源：

中国现代药物应用 | 2011年 / 5卷 / 11期

关键词：

晚期胃癌; 联合化疗; 替吉奥胶囊; 紫杉醇;

D O I：

10.14164/j.cnki.cn11-5581/r.2011.11.111

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

目的观察替吉奥胶囊(S-1)联合紫杉醇治疗晚期胃癌的近期疗效和毒副反应。方法初治和复治的晚期胃癌28例,替吉奥胶囊80mg/(m2·d),2次/d,连服14d,停药7d;紫杉醇160mg/m2,第1天静脉滴注,21d为1个周期,连用2周期后评价疗效。结果总有效率53.6%(15/28)。主要毒副反应为胃肠道反应、白细胞减少,Ⅲ～Ⅳ度各占7.2%(2/28)。结论治疗晚期胃癌,替吉奥胶囊联合紫杉醇21d方案是有效、经济和安全的。

引用

页码：3 / 4

页数：2

共 6 条

[1]

Phase II study of S-1 as first-line treatment for elderly patients over 75 years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study [J].

Koizumi, Wasaburo ;

Akiya, Toshikazu ;

Sato, Atsushi ;

Sakuyama, Toshikazu ;

Sasaki, Eisaku ;

Tomidokoro, Takashi ;

Hamada, Tsutomu ;

Fujimori, Mototsugu ;

Kikuchi, Yoshinori ;

Shimada, Ken ;

Mine, Tetsuya ;

Yamaguchi, Kensei ;

Sasaki, Tsuneo ;

Kurihara, Minoru .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2010, 65 (06) :1093-1099

[2]

Prediction of sensitivity to fluoropyrimidines by metabolic and target enzyme activities in gastric cancer [J].

Masanori Terashima ;

Hisataka Fujiwara ;

Akinori Takagane ;

Kaoru Abe ;

Takashi Irinoda ;

Tsutomu Nakaya ;

Hitoshi Yonezawa ;

Kenichi Oyama ;

Kazuyoshi Saito ;

Norio Kanzaki ;

Satoshi Ohtani ;

Tsuyoshi Nemoto ;

Yutaka Hoshino ;

Michihiko Kogure ;

Mitsukazu Gotoh .

Gastric Cancer, 2003, 6 (Suppl 1) :71-81

[3]

Reduction of 5-fluorouracil (5-FU) gastrointestinal (GI) toxicity resulting from the protection of thymidylate synthase (TS) in GI tissue by repeated simultaneous administration of potassium oxonate (Oxo) in rats [J].

Yoshisue, K ;

Hironaga, K ;

Yamaguchi, S ;

Yamamoto, A ;

Nagayama, S ;

Kawaguchi, Y .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2000, 46 (01) :51-56

[4]

现代肿瘤学.[M].汤钊猷; 主编.复旦大学出版社.2003,

[5]

Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent ( drug combination of tegafur; 5chloro-2; 4-dihydroxypyridine; and potassium oxonate) to rats..Yoshisue K; Masuda H; Matsushima E; et al;.Drug Metab Dispos.2000,

[6]

晚期胃癌化疗的现状和新进展 [J].

秦叔逵 ;

龚新雷 .

临床肿瘤学杂志, 2006, (09) :641-652

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