获取抗生素的新途径——沉默基因的激活

被引：4

作者：

顾觉奋

机构：

[1] 中国药科大学微生物制药教研室南京

来源：

国外医药(抗生素分册) | 2003年 / 05期

关键词：

沉默基因; 激活; 筛选新抗生素;

D O I：

10.13461/j.cnki.wna.003877

中图分类号：

TQ465 [抗菌素制造];

学科分类号：

100705 ;

摘要：

随着基因工程技术的不断发展和成熟 ,通过遗传学途径筛选新抗生素也得到了很快的发展。本文从遗传学途径出发 ,提出了筛选新抗生素的一种新思路———激活沉默基因。阐述了沉默基因的定义、理论依据、激活方法、实践意义等。并通过四个已获得成功的实例加以说明其在新抗生素筛选方面的进展。

引用

页码：193 / 197

页数：5

共 6 条

[1]

Drug discovery and development through the genetic engineering of antibiotic —production microorganisms. Hutchinson C R,Borell C W,Otten S L,et al. Journal of Medicinal Chemistry . 1989

[2]

Towards on understanding of gene switching in Streptomyces, the basis of sporulation and antibiotics production. Hopwood D A. Proc R Soc Lond( Biol) . 1988

[3]

Cloning of a pleiotropic gene that positively controls biosynthesis of A-factor, Actinorhodin and Prodigiosin in Streptomyces coelicolor A3(2) and Streptomyces lividans. Horininchi S,Hara O,Beppu T,et al. Journal of Bacteriology . 1983

[4]

Activation of phenoxazinone synthase expression in Streptomyces lividans by cloned DNA sequences for Streptomyces antibioticus. Jones G H,Hopwood D A. Journal of Biological Chemistry . 1984

[5]

Fresh approaches to antibiotic production. Hopwood D A,Chater K F. Philosophical Transactions of the Royal Society of London . 1980

[6]

Antibiotics: opportunities for genetic manipulation. Hopwood D A. Philosophical Transactions of the Royal Society of London . 1989

← 1 →