急性下呼吸道感染时H ib OMP特异抗体测定的意义

被引:1
作者
刘秀云
江载芳
杨永弘
机构
[1] 北京儿童医院!邮政编码
关键词
抗体测定; b型嗜血流感杆菌; 肺炎;
D O I
10.15932/j.0253-9713.1999.01.014
中图分类号
R725.6 [小儿呼吸系及胸部疾病];
学科分类号
100202 ;
摘要
我们建立了b 型流感嗜血杆菌(Hib)外膜蛋白(OMP)特异抗体测定的间接酶联免疫吸附法(ELISA),同时联合血、尿细菌抗原检测,对70 例肺炎患儿及30 例健康儿童进行研究。结果有19/70(27.1% 例)肺炎患儿产生Hib OMP抗体反应,除外1 例交叉反应,余18 例诊断为Hib 感染,其中5 例未查到Hib 抗原,以Hib OMP特异抗体反应得到诊断。表明Hib OMP抗体测定可提高小儿Hib 肺炎的病原诊断率。
引用
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页码:30 / 32
页数:3
相关论文
共 5 条
[1]  
Antibodies tohaem ophilus influenzas type b outer m em brane proteinsin children with epiglottitis or m eningitis and in haelthycontrols. Johnson PDR,Macinnes SJ,Gilbert GL. InfectIm m un . 1993
[2]  
Serumantibody response to capsular polysaccharide, outerm em brane, and lipooligosaccharide in children w ithinvasive haem ophilusinfluenzastypeb infections. Claesson BA,Lagergard T,Trollfors B,et al. JClinMicro . 1987
[3]  
Bacterialantibody assays in the diagnosis of acute low errespiratory tract infection in children. Nohynek H,Eskola J,Klaem ola M,et al. Pediatr InfectDisJ . 1995
[4]  
Measurem entof antibody responses to pneum olysin——a prom isingm ethod for the presum ptive aetiological diagnosis ofpneum ococalpneum onia. Jalonen E,Paton JC,Koskela M,et al. JInfect . 1989
[5]  
Theaetiology of pneum onia.Application of bacterialserology and basic laboratory m ethods. Kerttula Y,Leinonen M,Koskela M,et al. JInfect . 1987