Clinicopathologic significance of expression of nuclear factor-kB RelA and its target gene products in gastric cancer patients

被引：8

作者：

Hyuk-Chan Kwon ^{[1
]}

Sung-Hyun Kim ^{[1
]}

Sung Yong Oh ^{[1
]}

Suee Lee ^{[1
]}

Ji Hyun Lee ^{[1
]}

Jin Seok Jang ^{[1
]}

Min Chan Kim ^{[2
]}

Ki Han Kim ^{[2
]}

Su-Jin Kim ^{[3
]}

Seong-Geun Kim ^{[4
]}

Hyo-Jin Kim ^{[1
]}

机构：

[1] Department of Internal Medicine,Dong-A University College of Medicine,Busan 602-715,South Korea

[2] Department of Surgery,Dong-A University College of Medicine,Busan 602-715,South Korea

[3] Department of Pathology,Dong-A University College of Medicine,Busan 602-715,South Korea

[4] Research Institute for Convergence of Biomedical Science and Technology,Pusan National University Yangsan Hospital,Busan 602-715,South Korea

来源：

World Journal of Gastroenterology | 2012年 / 34期

关键词：

Nuclear factor-kB; Vascular endothelial growth factor; Interleukin-6; C-reactive protein; Serum amyloid A; Stomach; Carcinoma;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100214 ;

摘要：

AIM:To assess the prognostic significance of nuclear factor-kB (NF-kB) and its target genes in gastric cancer. METHODS:The tumor tissues of 115 patients with gastric cancer were immunohistochemically evaluated using monoclonal antibodies against NF-kB RelA. Preoperative serum levels of vascular endothelial growth factor (VEGF), interleukin-6 (IL-6) were assessed via enzyme-linked immuno-sorbent assay. C-reactive protein (CRP) and serum amyloid A (SAA) were measured via immunotrubidimetry. RESULTS:Positive rate of NF-kB RelA was 42.6%. NF-kB RelA expression in tumor tissues was also related to serum levels of IL-6 (P = 0.044) and CRP (P = 0.010). IL-6, SAA, CRP were related to depth of invasion, VEGF and SAA were correlated with lymph node metastasis. IL-6, VEGF, SAA and CRP were related to the stage. Univariate analysis demonstrated that immunostaining of NF-kB RelA, levels of IL-6, VEGF, SAA were significantly related with both disease free survival and over-all survival (OS). Multivariate analysis verified that NF-kB RelA [hazard ratio (HR): 3.40, P = 0.024] and SAA (HR: 3.39, P = 0.045) were independently associated with OS. CONCLUSION: Increased expression of NF-kB RelA and high levels of serum SAA were associated with poor OS in gastric cancer patients.

引用

页码：4744 / 4750

页数：7

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