肢端肥大症患者治疗前后血清生长激素非均一性的变化

被引:7
作者
张秀兰
邓洁英
金自孟
史轶蘩
机构
[1] 首都医院内分泌科
关键词
肢端肥大症; 生长激素; 病情; 垂体机能亢进; 患者; 血清; 正常人; 治疗前后;
D O I
暂无
中图分类号
学科分类号
摘要
为探讨肢端肥大症患者血清生长激素(hGH)水平与病情不完全平行的机制,本文对6例正常人和17例肢端肥大症患者治疗前后血清的非均一性进行了研究。结果正常人及肢端肥大症患者“小hGH”在hGH的总量中分别为34.4±10.2%及69.8±13.9%。患者明显高于正常人(P<0.001)。治疗好转9例小hGH的百分比降至48.7±11.8%,而未好转的2例,小hGH的比例未变。我们认为人血清hGH是非均一的,其中有生物活性的小hGH的量比总量更能准确地反映病情的轻重。
引用
收藏
页码:21 / 24
页数:4
相关论文
共 5 条
[1]  
Evidence for higher proportion of"little"growth hormone With increased radioreceptor activity in acromegalic plasma. Gorden P,et al. Journal of Clinical Endocrinology and Metabolism . 1976
[2]  
Heterogeneity of peptide hermone. Yalow RS. Recent Progress in Hormone Research . 1974
[3]  
Human Growth Hormone:Cha-racterization of plasma and pituitary components and application of a new radioreceptor assay. Gorden P,et al. . 1974
[4]  
Studies on"big"growth hormone from human plasma and pituitary. Wright DR,et al. The Journal of Clinical Investigation . 1974
[5]  
Heterogeneity of circulating growth Hormone in acromegaly. Dimond RC. Journal of Clinical Endocrinology and Metabolism . 1974