EGFR酪氨酸激酶区域基因变异与吉非替尼治疗非小细胞肺癌临床因素相关性研究进展

被引:3
作者
赵向飞
刘晓晴
机构
[1] 军事医学科学院附属医院肿瘤一科
关键词
EGFR突变; 非小细胞肺癌; 吉非替尼;
D O I
暂无
中图分类号
R734.2 [肺肿瘤];
学科分类号
100214 ;
摘要
吉非替尼是表皮性生长因子受体(EGFR)酪氨酸激酶抑制剂,在非小细胞肺癌的治疗中受到普遍关注,而EGFR突变有助于筛选针对吉非替尼治疗的受益人群,本文回顾了近期国外对EGFR突变及其与病理类型、种族、性别、生存期等临床因素的相关性。
引用
收藏
页码:1438 / 1441
页数:4
相关论文
共 35 条
[1]  
EGFR Mutation of Tumor and Serum in Gefitinib-Treated Patients with Chemotherapy-Naive Non–small Cell Lung Cancer[J] . Hideharu Kimura,Kazuo Kasahara,Kazuhiko Shibata,Takashi Sone,Akihiro Yoshimoto,Toshiyuki Kita,Yukari Ichikawa,Yuko Waseda,Kazuyoshi Watanabe,Hiroki Shiarasaki,Yoshihisa Ishiura,Masayuki Mizuguchi,Yasuto Nakatsumi,Tatsuhiko Kashii,Masashi Kobayashi,Hideo Kunitoh,Tomohide Tamura,Kazuto Nishio,Masaki Fujimura,Shinji Nakao. &nbspJournal of Thoracic Oncology . 2006 (3)
[2]   Comparative analysis of epidermal growth factor receptor mutations and gene amplification as predictors of gefitinib efficacy in Japanese patients with nonsmall cell lung cancer [J].
Sone, Takashi ;
Kasahara, Kazuo ;
Kimura, Hideharu ;
Nishio, Kazuto ;
Mizuguchi, Masayuki ;
Nakatsumi, Yasuto ;
Shibata, Kazuhiko ;
Waseda, Yuko ;
Fujimura, Masaki ;
Nakao, Shinji .
CANCER, 2007, 109 (09) :1836-1844
[3]  
Epi-dermal growth factor receptor mutations in needle biopsy/aspira-tion samples predict response to Gefitinib therapy and survival of patients with advanced non small cell lung cancer. Jin-Yuan Shih,Chien-Hung Gow,Chong-Jen Yu1,et al. International Journal of Cancer . 2006
[4]  
Epider-mal growth factor receptor gene mutation and computed tomo-graphic findings in peripheral pulmonary adenocarcinoma. Motoki Yano,Hidefumi Sasaki,Yoshihiro Kobayashi,et al. JThorac Oncol . 2006
[5]  
EG-FR mutation is specific for terminal respiratory unit type adenocar-cinoma. Yasushi Yatabe,Takayuki Kosaka,Takashi Takahashi,et al. The American Journal of Surgical Pathology . 2005
[6]  
Mu-tation and polymorphism in the EGFR-TK domain associated with lung cancer. Weiping Zhang,Laura P Stabile,Phouthone Keohavong,et al. J Thorac Oncol . 2006
[7]  
EGFR and ErbB2mutation status in Japanese lung cancer patients. Hidefumi Sasaki,Shigeki Shimizu,Katsuhiko Endo,et al. International Journal of Cancer . 2006
[8]  
Optimiza-tion of patient selection for Gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation,K-ras mutation,and Akt phosphorylation. Sae-Won Han,Tae-You Kim,Yoon Kyung Jeon,et al. Clinical Cancer Research . 2006
[9]  
Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer:Molecular analysis of the IDEAL/INTACT gefitinib trials. Daphne W Bell,,Thomas J Lynch,Sara MHaserlat,et al. Journal of Clinical Oncology . 2005
[10]  
Identification of EGFR kinase domain mutations among lung cancer patients in Chi-na:implication for targeted cancer therapy. Bao Ming QIN,Xiao CHEN,Jing De ZHU,et al. Cell Research . 2005