重组白介素6-假单胞菌外毒素融合蛋白对正常BN大鼠骨髓粒系造血的作用

被引：4

作者：

奚永志

唐佩弦

ACMMartens

AHagenbeek

DJ FitzGerald

机构：

[1] 军事医学科学院基础医学研究所,军事医学科学院基础医学研究所,Institute,Institute,NationalCancerInstitute,Bethesda,USA北京,北京,ofAppliedRadiobiology＆Immunology,TNO,NL,ofAppliedRadiobiology＆Immunology,TNO,NL

来源：

中国应用生理学杂志 | 1993年 / 03期

关键词：

IL-6-PE40; BN大鼠; 粒系造血;

D O I：

10.13459/j.cnki.cjap.1993.03.012

中图分类号：

学科分类号：

摘要：

本文报道了重组白介素6-假单胞菌外毒素融合蛋白(IL-6-PE40)对正常BN大鼠骨髓粒系造血的体外效应。10ng/ml的IL-6-PE40对高表达IL-6受体的U266骨髓瘤细胞的蛋白质合成抑制率为50％,1000ng/ml则为100％。1～1000ng/mlIL-6-PE40对正常骨髓未纯化细胞的CFU-GM集落形成和DNA合成无明显抑制,但IL-6却具有一定的刺激效应。提示正常骨髓粒系祖细胞和骨髓细胞可能不表达IL-6受体,IL-6-PE40对粒系造血仍具有某些细胞毒作用,但被IL-6-PE40中的IL-6极大地削弱了。

引用

页码：51 / 55

页数：5

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