梅毒血清固定与神经梅毒患者淋巴细胞亚群的检测

被引：16

作者：

凌昕

刘润秋

施辛

季孙平

孙晓东

季江

机构：

[1] 苏州大学附属第二医院皮肤科

来源：

中国皮肤性病学杂志 | 2010年 / 24卷 / 05期

关键词：

梅毒; 淋巴细胞亚群; 流式细胞仪; 神经梅毒; 血清固定;

D O I：

暂无

中图分类号：

R759.1 [梅毒];

学科分类号：

100206 ;

摘要：

目的探讨梅毒治疗有效、血清固定、神经梅毒与外周血淋巴细胞(PBLC)亚群的关系。方法应用流式细胞仪检测20例梅毒治疗有效患者、23例梅毒血清固定患者、16例神经梅毒患者及20例健康人群的外周血淋巴细胞亚群。结果各组梅毒患者外周血CD4细胞(分别为29.79±5.47,31.79±6.72,33.84±8.81)、CD4/CD8比值(分别为1.34±0.46,1.54±0.70,1.62±0.67)均显著低于对照组(分别为43.50±8.93,2.20±0.43)(P<0.01);治疗有效组患者B细胞(CD19,12.26±3.43)显著高于对照组(9.00±2.04)(P<0.01),NK细胞(16.81±6.95)显著低于对照组(26.35±9.93,P<0.05);血清固定组患者NK细胞(15.82±8.44)显著低于对照组(P<0.01)。结论T淋巴细胞亚群的改变和NK细胞减少与梅毒血清固定和发展成神经梅毒推断有一定关系。

引用

页码：418 / 420

页数：3

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