内皮祖细胞参与肿瘤血管发生的问题与展望

被引:7
作者
冯文都 [1 ,2 ]
余德才 [1 ,2 ]
丁义涛 [1 ,2 ]
机构
[1] 南京大学附属鼓楼医院肝胆外科
[2] 南京大学肝胆研究所江苏省肝胆疾病临床医学中心
关键词
D O I
暂无
中图分类号
R730.2 [肿瘤病理学、病因学];
学科分类号
100214 [肿瘤学];
摘要
<正>血管新生对肿瘤至关重要,肿瘤生长、侵袭及转移均伴随着血管新生。研究证实,肿瘤可以通过募集骨髓源性内皮祖细胞(EPCs),分化为血管内皮,产生新生血管,促进肿瘤生长。随着本实验室和其他研究小组的不断研究,我们对EPCs参与血管发生的机制的了解逐步深入。越来越多的动物实验证实,EPCs在肿瘤的发生、发展和转移过程中扮演重要角色。一系列临床研究也表明:循环和肿瘤组织EPCs不仅能够反映
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