药物促进骨形成——骨质疏松症治疗新举措

被引：23

作者：

沈龙祥

曾炳芳

机构：

[1] 上海交通大学附属第六人民医院骨科

来源：

国际骨科学杂志 | 2016年 / 37卷 / 03期

关键词：

骨质疏松; 特立帕肽; 骨形成;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

骨质疏松症是人体骨吸收与骨形成不平衡的结果,抑制骨吸收和促进骨形成均可治疗骨质疏松。特立帕肽是全长甲状旁腺素(PTH)的N末端第1～34个氨基酸片断,其重组形式复泰奥是迄今唯一被美国食品药品监督管理局(FDA)批准用于治疗骨质疏松症的促骨形成药物。众多随机对照试验显示,特立帕肽能升高血清骨形成标志物,增加骨密度,降低骨质疏松性骨折发生风险,其抑制骨吸收的效果优于双膦酸盐。美国推荐特立帕肽治疗高骨折风险的骨质疏松,加拿大则推荐特立帕肽为治疗严重骨质疏松的一线药物。

引用

页码：135 / 140

页数：6

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