冷冻止痛的机理研究

被引：18

作者：

周林球

邵振海

区士欢

机构：

[1] 第一军医大学珠江医院骨科

[2] 第一军医大学珠江医院病理科

来源：

解放军医学杂志 | 1992年 / 02期

关键词：

冷冻止痛; 周围神经; 最佳温度;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

不同温度(-20℃、-60℃、-100℃、-140℃和-180℃)冷冻家兔坐骨神经后,不同时期以HE、组化染色进行光镜,超薄切片电镜及体感诱发电位(SSEP)、感觉神经传导速度(SCV)、肌电图(EMG)等观察。结果-20℃冷冻,神经形态与功能无明显变化;-60℃冷冻,神经开始变性,传导功能丧失,但神经可以通过自身代谢修复;-100℃冷冻约半数的神经纤维发生Wallerian变性,神经修复时间延长,而神经仍能完全再生修复;-140℃与-180℃冷冻,神经立即坏死,部分基膜破坏,胶原纤维增生,神经形态与功能不能完全修复。本结果解释了临床深低温冷冻止痛效果好的原因,提示低于-140℃为冷冻止痛的最佳温度。

引用

页码：96 / 99

页数：4

共 9 条

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