白细胞介素17抑制剂secukinumab在银屑病中的应用

被引：7

作者：

徐飞

杨君义

机构：

[1] 临沂市沂水中心医院药学部

来源：

中国新药与临床杂志 | 2016年 / 35卷 / 03期

关键词：

secukinumab; 银屑病; 白细胞介素17; 抑制剂;

D O I：

10.14109/j.cnki.xyylc.2016.03.007

中图分类号：

R758.63 [牛皮癣（银屑病）];

学科分类号：

100227 [皮肤病学];

摘要：

secukinumab为一种全人源化单克隆免疫球蛋白G1κ抗体,通过选择性结合并中和白细胞介素17A而发挥作用。可皮下或静脉给药,对中重度斑块状银屑病具有较好疗效。患者对secukinumab有较好的耐受性,最常见的不良反应为鼻咽炎、头痛、上呼吸道感染等。

引用

页码：182 / 184

页数：3

共 7 条

[1]

Efficacy, safety and usability of secukinumab administration by autoinjector/pen in psoriasis: a randomized, controlled trial (JUNCTURE) [J].

Paul, C. ;

Lacour, J. -P. ;

Tedremets, L. ;

Kreutzer, K. ;

Jazayeri, S. ;

Adams, S. ;

Guindon, C. ;

You, R. ;

Papavassilis, C. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2015, 29 (06) :1082-1090

[2]

Secukinumab administration by pre-filled syringe: efficacy, safety and usability results from a randomized controlled trial in psoriasis (FEATURE) [J].

Blauvelt, A. ;

Prinz, J. C. ;

Gottlieb, A. B. ;

Kingo, K. ;

Sofen, H. ;

Ruer-Mulard, M. ;

Singh, V. ;

Pathan, R. ;

Papavassilis, C. ;

Cooper, S. .

BRITISH JOURNAL OF DERMATOLOGY, 2015, 172 (02) :484-493

[3]

The Role of Interleukin-17A in Psoriatic Disease [J].

Adami, Silvano ;

Cavani, Andrea ;

Rossi, Francesco ;

Girolomoni, Giampiero .

BIODRUGS, 2014, 28 (06) :487-497

[4]

Secukinumab in Plaque Psoriasis - Results of Two Phase 3 Trials [J].

Langley, Richard G. ;

Elewski, Boni E. ;

Lebwohl, Mark ;

Reich, Kristian ;

Griffiths, Christopher E. M. ;

Papp, Kim ;

Puig, Lluis ;

Nakagawa, Hidemi ;

Spelman, Lynda ;

Sigurgeirsson, Bardur ;

Rivas, Enrique ;

Tsai, Tsen-Fang ;

Wasel, Norman ;

Tyring, Stephen ;

Salko, Thomas ;

Hampele, Isabelle ;

Notter, Marianne ;

Karpov, Alexander ;

Helou, Silvia ;

Papavassilis, Charis .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (04) :326-338

[5]

Interleukin 17A: Toward a new understanding of psoriasis pathogenesis [J].

Lynde, Charles W. ;

Poulin, Yves ;

Vender, Ronald ;

Bourcier, Marc ;

Khalil, Sam .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2014, 71 (01) :141-150

[6]

Efficacy and Safety of Secukinumab in Chronic Plaque Psoriasis and Psoriatic Arthritis Therapy [J].

Gisondi P. ;

Dalle Vedove C. ;

Girolomoni G. .

Dermatology and Therapy, 2014, 4 (1) :1-9

[7]

Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study [J].

Rich, P. ;

Sigurgeirsson, B. ;

Thaci, D. ;

Ortonne, J. -P. ;

Paul, C. ;

Schopf, R. E. ;

Morita, A. ;

Roseau, K. ;

Harfst, E. ;

Guettner, A. ;

Machacek, M. ;

Papavassilis, C. .

BRITISH JOURNAL OF DERMATOLOGY, 2013, 168 (02) :402-411

← 1 →