热激蛋白70研究进展

被引：40

作者：

杨秉芬 ^{[1
,2
]}

孙启鸿 ^{[2
]}

曹诚 ^{[1
]}

机构：

[1] 军事医学科学院生物工程研究所

[2] 军事医学科学院放射与辐射医学研究所

来源：

生物技术通讯 | 2009年 / 20卷 / 05期

关键词：

热激蛋白70; 细胞凋亡; 免疫;

D O I：

暂无

中图分类号：

Q51 [蛋白质];

学科分类号：

070307 [化学生物学];

摘要：

热激蛋白70(HSP70)是广泛存在且高度保守的蛋白,作为伴侣分子能够促进蛋白折叠;HSP70可以通过阻止细胞色素c从线粒体释放,与凋亡诱导因子结合使其不能入核,或者抑制JNK激酶活性调节细胞凋亡;HSP70可以调节细胞周期进程,促进细胞生长,阻止细胞衰老;免疫功能研究表明HSP70是有效的免疫佐剂,可激发抗原特异性的CTL反应,同时细胞外HSP70和膜结合HSP70可激发非特异性免疫反应。

引用

收藏

页码：716 / 718+748 +748

页数：4

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