金黄地鼠高脂血症动物模型的应用研究

被引：16

作者：

唐世英

胡桂才

李可基

肖颖

李来

机构：

[1] 承德医学院预防医学教研室

[2] 承德医学院附属医院心内科

[3] 北京大学运动医学研究所

[4] 北京大学公卫学院营养与食品卫生教研室

[5] 承德医学院预防医学教研室河北承德

[6] 河北承德

来源：

承德医学院学报 | 2002年 / 03期

关键词：

高脂血症; 金黄地鼠; 动物模型; 胆固醇; 甘油三酯;

D O I：

10.15921/j.cnki.cyxb.2002.03.002

中图分类号：

R589.2 [脂肪代谢障碍];

学科分类号：

1002 ; 100201 ;

摘要：

目的 :建立金黄地鼠高脂血症模型。方法 :按血浆 TC将 6～ 8周龄雄性金黄地鼠随机分成普通组和高脂组 ,分别饲以胆固醇含量为 0 .0 2 2 %和 0 .2 %、脂肪含量为 4 %和 2 0 %的饲料。每周采血一次 ,测定血浆 TC、TG。结果 :第三至四周动物 TC、TG达到较稳定水平 ,与普通组比较 ,高脂组动物 TC升高了近 2倍 ,TG升高近 1倍。结论 :建立金黄地鼠高脂血症模型所用饲料胆固醇含量低、造模时间短 ,是研究人类脂代谢的理想模型之一。

引用

页码：173 / 175

页数：3

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