雷公藤红素诱导多发性骨髓瘤细胞系凋亡及对其细胞周期的影响

被引:7
作者
谢勇
机构
[1] 山西大同大学医学院
关键词
雷公藤红素; 多发性骨髓瘤; 凋亡; 细胞周期;
D O I
10.13412/j.cnki.zyyl.2009.06.039
中图分类号
R733.3 [骨髓肿瘤];
学科分类号
100214 ;
摘要
目的:研究雷公藤红素对多发性骨髓瘤细胞系KMS12和KMS18的抑制作用及机理,以及对细胞周期的影响。方法:用CCK-8法研究抑制作用;凋亡检测采用V-Annexin-FITC和PI双染色法以及sub-S1法。流式细胞仪检测细胞周期。结果:雷公藤红素1μmol/L可抑制多发性骨髓瘤细胞系增殖,并诱导细胞凋亡。对细胞的S0期、S期、G2/M期均有影响。结论:雷公藤红素可引起多发性骨髓瘤细胞系凋亡并影响其细胞周期,具有潜在的临床应用价值。
引用
收藏
页码:17 / 20
页数:4
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