N-端脑钠肽前体测定在高血压疾病中的应用研究

被引：5

作者：

李小侠

詹颉

张华

党小军

赵海

奚逢瑜

李博

机构：

[1] 陕西省人民医院检验科

来源：

现代检验医学杂志 | 2016年 / 31卷 / 05期

关键词：

脑钠肽; N-端脑钠肽前体; 高血压; 糖尿病;

D O I：

暂无

中图分类号：

R544.1 [高血压]; R446.1 [生物化学检验、临床检验];

学科分类号：

100201 [内科学]; 100208 [临床检验诊断学];

摘要：

目的探讨血清N端脑钠肽前体(NT-proBNP)在高血压疾病的应用研究。方法选择152例高血压患者纳入研究,根据高血压病情发展分为高血压1级(30例),高血压2级(36例)和高血压3级(86例)。86例高血压3级患者根据有无并发糖尿病又分为单纯高血压组(40例)和高血压并发糖尿病组(46例),分别比较不同分级组的血清NT-proBNP水平变化。结果高血压1级患者、2级患者和3级患者血清中NT-proBNP水平分别为68±44,122±31和834±309 pg/ml。随着病情发展其血清水平逐渐升高(t=2.455,3.561,P<0.01),高血压3级患者中高血压并发糖尿病组和单纯高血压组血清中NT-proBNP分别为1 178±664 pg/ml和599±411 pg/ml(t=3.785,P<0.01)。结论 NT-proBNP水平能客观反映高血压患者的病情程度,对临床治疗和病情监测有一定的指导意义。

引用

页码：100 / 102

页数：3

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